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Cured Mice Sickle Cell Anemia Skin Cells Stem
   
Using a recently developed technique for turning skin cells into stem cells, scientists have cured mice of sickle cell anemia -- the first direct proof that the easily obtained cells can reverse an inherited, potentially fatal disease.
Researchers said the work, published in yesterday's online edition of the journal Science, points to a promising future for the novel cells. Known as iPS cells, they have been touted by President Bush and some scientists as a possible substitute for embryonic stem cells, which have been mired for years in political controversy.
The cells are dubbed induced Pluripotent Stem cells, iPS cells for short. Last month it was shown that the cells could be created as easily from human skin tissue as mouse skin tissue. Further, the research showed that the iPS cells behaved like true stem cells and could differentiate into the more than 200 types of cells in the human body.
"All the progress in this field was only possible because we had embryonic stem cells to work with first," said Rudolf Jaenisch, who led the new study.
But researchers also cautioned that aspects of the new approach will have to be changed before it can be tried in human patients. Most important, the technique depends on the use of gene-altered viruses that have the potential to trigger tumor growth.
The reason for Whitehead's reluctance is that they are trying to change aspects of their creation approach in order to make it human safe. Researchers currently utilize genetically modified viruses in the induction process. The viruses have the potential to trigger tumor growth in healthy mammalian tissues.
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